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Recent research from Singapore questions whether two doses of COVID-19 vaccine are sufficient for children, exploring the necessity of booster shots amid variant concerns. Since the start of the COVID-19 pandemic, extensive research in epidemiology, clinical practice, and virology has greatly increased our understanding of the virus and its impact on human health.

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The Duke-NUS research team, collaborating with Duke University and the National University of Singapore, conducted a preclinical comparison between nasal and subcutaneous administration of the COVID-19 vaccine. Their findings were published in eBioMedicine. It revealed that the intranasal route not only induces a strong mucosal antibody response but also enhances long-term mucosal and systemic immune protection.