Author: kethleen loh

Positive outcomes from two phase 3 trials suggest that Gepotidacin, an investigational oral antibiotic, holds promise as a groundbreaking, first-in-class medication for managing uncomplicated urinary tract infections (UTIs) in female adolescents and adults. Clinical Background of UTI UTIs rank as the most prevalent infections treated on an outpatient basis in the United States, with a lifetime occurrence rate of 50-60% among adult women [1]. Although Southeast Asia reported a low age-standardized incidence rate of 2.5% in 2019 [2], UTIs remain a common infection that becomes more prevalent with age, particularly in women. Among the various classifications of UTIs, an uncomplicated…

The FDA has announced updates to the prescribing information and safety labelling for all prescription opioid medicines, including both immediate-release (IR) and extended-release/long-acting (ER/LA) formulations. These updates include the addition of a new warning regarding the risk of opioid-induced hyperalgesia (OIH), cautionary notes on the extended use of opioid products and reordering of information in the Boxed Warning [1]. Opioids Overview Opioids are therapeutic agents commonly used for moderate to severe acute and chronic pain [2], particularly when other treatments have been ineffective. Opioid receptors are classified into μ (Mu), δ (delta) and κ (kappa) receptors, as well as the…

Omisirge is used in adults and children aged 12+ for cord blood transplant after myeloablative conditioning in hematologic malignancies.

A study in Denmark found that short-term use of NSAIDs increases heart failure hospitalization risk in type 2 diabetes patients. Read more