Curious about the difference between PDRN and PDLLA? These two powerful skin boosters work in different ways – one heals, the other rebuilds. Here’s what they do, how they work, and how to combine them safely for glowing, firmer skin.
While forehead wrinkles and crow’s feet around the eyes are a natural part of ageing, today’s society has a different definition of beauty.
The field of skin aesthetics is advancing rapidly. The desire for smooth and radiant skin is growing, regardless of age or gender. This is where skin-boosting treatments come to play and make wonders. Among the most talked-about options currently are PDRN and PDLLA, two emerging stars in the world of aesthetic medicine.
So, what exactly are PDRN and PDLLA?
If these terms are unfamiliar to you, fret not!
What Happens to the Skin as We Age?
Our skin loses its elasticity and firmness gradually with age due to the natural decline in collagen and elastin production.
These skin changes may manifest as:
- Wrinkles or sagging skin.
- Drier skin from reduced sebum (oil) production.
- Pigmentation or uneven skin tone.
- Increased bruising from fragile blood vessels under the skin.
The skin ageing process can be accelerated by external factors:
- Excessive sun exposure
- Smoking
- Environmental pollutants
- Hormonal changes (e.g. menopause)
What is PDRN?
PDRN is polydeoxyribonucleotide. It is a skin-healing molecule derived from purified DNA fragments of salmon or trout. Known for its anti-inflammatory property, PDRN acts on the cellular level to promote collagen synthesis and skin repair.
Key Benefits
- Improves overall skin texture (e.g. fine lines, wrinkles, large pores and acne scars).
- Enhances skin hydration.
- Reduces inflammation.
- Supports skin recovery after energy-based or injectable procedures.
What is PDLLA?
PDLLA (Poly-D,L-Lactic Acid) is a synthetic and biocompatible agent that works deeper within the skin. It triggers low-level inflammatory response to activate fibroblasts (cells that produce collagen in the skin) for long-term collagen regeneration.
Key Benefits
- Long-lasting firming and volumising effect.
- Strengthens skin structure and elasticity.
- Restores skin contour.
PDRN or PDLLA – Which Should You Choose?
Dr. Paul Yow, Director of Aesthetic Medicine in Eagle Aesthetics & Surgery, shared some tips to choose between these two skin boosters.
| Choose PDRN | Choose PDLLA |
|
|
💡 Pro tip: Start with PDRN to build foundational skin health, then switch to PDLLA for deeper collagen stimulation.
Can You Combine Both?
Absolutely.
“When used thoughtfully, combining PDRN and PDLLA can create a synergistic effect for skin rejuvenation,” said Dr. Paul.
Since PDRN is anti-inflammatory and PDLLA is pro-inflammatory, it’s essential to space the treatments (typically 1 – 2 weeks apart) to allow each to work effectively. This approach ensures both treatments can complement each other while enhancing and restoring the skin.
Key Takeaways
Both PDRN and PDLLA are highly effective options, but they target different skin concerns. Together, they address both short-term glow and long-term anti-ageing.
Healthy, youthful skin doesn’t happen overnight. It requires a combination of good skincare habits, expert guidance and tailored cosmetic treatments. Always consult qualified dermatologists to design a treatment plan suited to your skin goals.
References
- How Does Aging Affect Your Skin? Heathline. Updated: 22 September 2025. https://www.healthline.com/health/senior-health/aging-skin
- Pigmentation Woes After Laser? Here’s What Might Be Happening. Medical Channel Asia. Updated: 8 October 2025. https://medicalchannelasia.com/pigmentation-woes-after-laser-heres-what-might-be-happening/
- What is PDRN – and why is salmon sperm the hottest K beauty trend right now? CNA Lifestyle. Updated: 11 March 2025. https://cnalifestyle.channelnewsasia.com/style-beauty/k-beauty-pdrn-salmon-sperm-460441
- Can You Actually Restore and Stimulate Collagen Production? Medical Channel Asia. Updated: 12 August 2025. https://medicalchannelasia.com/can-you-actually-restore-and-stimulate-collagen-production/
- https://eagleeyeaesthetics.com.sg/doctors/dr-paul-yow/
- Is Your Skin Routine Missing This Professional Step? Medical Channel Asia. Updated: 28 September 2025. https://medicalchannelasia.com/is-your-skin-routine-missing-this-one-professional-step/
