Woman in Japan Dies of Oz Virus, First Death Worldwide


A woman in her 70s from Ibaraki prefecture, Japan, has tragically become the world’s first reported fatality from the Oz virus, a potentially tick-borne infection. 

The virus, discovered in 2018, had raised suspicions of human and animal cases. However, this is the first confirmed onset in a person. The woman sought medical attention in the summer of 2022 after experiencing symptoms such as fever and fatigue. Although initially diagnosed with pneumonia, her condition worsened. She was hospitalised, where an engorged tick was found on her upper right thigh. Unfortunately, she passed away 26 days later from myocarditis, an inflammation of the heart muscle.

The Oz Virus and its Geographic Presence

The Oz virus, primarily found in Japan, was first identified in the Amblyomma testudinarium tick in Ehime prefecture. As of now, there have been no reports of the virus outside Japan. The National Institute of Infectious Diseases in Tokyo has clarified that infection with the Oz virus is not necessarily fatal. However, further research is needed to understand its symptoms and potential dangers. The virus is believed to be transmitted through tick bites. The Amblyomma testudinarium tick species is prevalent across various regions of Japan.

Presence of Antibodies in Wildlife and Humans

Several prefectures have discovered antibodies against the Oz virus in wild monkeys, boars, and deer. Six prefectures where these animals have tested positive for Oz virus antibodies. There are Chiba, Gifu, Mie, Wakayama, Yamaguchi, and Oita prefectures. Additionally, two hunters from Yamaguchi have reportedly tested positive for the antibodies, indicating possible exposure to the virus. This raises concerns about the potential spread of the virus to humans who come into contact with infected ticks.

Prevention Measures and Government Response

In response to this tragic event, the Ministry of Health, Labour, and Welfare in Japan emphasizes the importance of taking preventive measures when entering grassy areas where ticks may be present. They advise covering as much skin as possible to avoid tick bites. Public awareness campaigns will play a crucial role in educating the population about tick-borne infections and the necessary precautions to minimize the risk of transmission.

Research and Collaboration for Future Protection

The discovery of the Oz virus and its unfortunate consequences underscore the importance of ongoing research, surveillance, and public health efforts to combat emerging infectious diseases. The medical community and authorities must remain vigilant, collaborate on further studies, and explore potential preventive strategies to protect individuals from this tick-borne virus. Understanding the epidemiology, clinical manifestations, and transmission dynamics of the Oz virus is crucial for developing effective preventive measures and treatment options.


The world’s first reported death from the Oz virus in Japan serves as a solemn reminder of the potential risks posed by tick-borne infections. Currently, the virus has only been detected in Japan so far. However, global vigilance is necessary to monitor its spread and prevent further cases. Government agencies, healthcare professionals, and the public must work together. Therefore, they need to raise awareness, implement preventive measures, and support ongoing research to mitigate the impact of tick-borne diseases. By doing so, we can strive to protect individuals and communities from the dangers posed by emerging infectious diseases like the Oz virus.

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