Understanding Sjögren’s Syndrome: The Dry-Mouth Syndrome

Sjögren's syndrome

Sjögren’s syndrome is a chronic autoimmune disorder that affects the moisture-producing glands in the body, leading to dryness of the eyes, mouth, and other areas. This condition can cause discomfort and difficulty with everyday activities, and it’s important to understand the symptoms, causes, and treatment options available. 

A study conducted in Japan found that the prevalence of Sjögren’s syndrome was 0.4% among a general population of adults aged 40-69 years. In this article, we will look at this condition in more detail. 

Symptoms of Sjögren’s Syndrome

The hallmark symptom of Sjögren’s syndrome is dryness, which can affect the eyes, mouth, skin, and other areas of the body. The eyes may feel gritty or burning, and there may be a decreased ability to produce tears. The mouth may feel dry or sticky, and there may be difficulty with speaking, chewing, or swallowing. Other symptoms can include:

  • Joint pain and stiffness
  • Fatigue and weakness
  • Swollen salivary glands
  • Dry skin, nose, and throat
  • Vaginal dryness
  • Skin rashes
  • Persistent cough

Causes of Sjögren’s Syndrome

The exact cause of Sjögren’s syndrome is unknown, but it is believed to be related to a malfunction of the immune system. In people with this condition, the immune system attacks and damages the glands that produce tears and saliva, as well as other tissues in the body. Certain factors may increase the risk of developing Sjögren’s syndrome, including:

  • Being female
  • Being over the age of 40
  • Having a family history of autoimmune diseases
  • Having other autoimmune disorders, such as rheumatoid arthritis or lupus

Diagnosis of Sjögren’s Syndrome

Diagnosing Sjögren’s syndrome can be challenging, as the symptoms can be similar to other conditions. A doctor may perform a physical examination, review medical history, and order tests to evaluate the function of the glands and detect autoantibodies, which are proteins produced by the immune system. Some tests that may be used to diagnose Sjögren’s syndrome include:

  • Schirmer’s test: Measures the amount of tears produced by the eyes
  • Salivary flow rate test: Measures the amount of saliva produced by the glands
  • Blood tests: Look for specific autoantibodies associated with Sjögren’s syndrome
  • Lip biopsy: A small piece of tissue is removed from the lip to look for signs of inflammation and damage to the glands

Treatment of Sjögren’s Syndrome

There is no cure for Sjögren’s syndrome, but there are treatment options available to manage the symptoms and prevent complications. The treatment plan may depend on the severity of the condition and the individual’s specific symptoms. Some treatment options may include:

  • Artificial tears or lubricating eye drops to relieve dry eyes
  • Saliva substitutes or medications to increase saliva production to relieve dry mouth
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) or corticosteroids to relieve joint pain and inflammation
  • Immunosuppressive medications to suppress the immune system and prevent further damage to the glands and other tissues

In addition to medical treatment, lifestyle changes may also help manage the symptoms of Sjögren’s syndrome. Some tips to help relieve dryness and improve overall well-being may include:

  • Drinking plenty of fluids
  • Chewing sugar-free gum or candy to stimulate saliva production
  • Using a humidifier to add moisture to the air
  • Avoiding alcohol, caffeine, and tobacco, which can worsen dryness
  • Eating soft, moist foods and avoiding spicy or acidic foods that can irritate the mouth and throat


Sjögren’s syndrome can be a challenging condition to manage, but with proper treatment and self-care, many people with this condition can live full and active lives. Therefore, it is important to work closely with a healthcare provider to develop a treatment plan that meets your individual needs and to seek medical attention if you experience any new or worsening symptoms.

If you suspect that you may have Sjögren’s syndrome, it’s important to seek medical attention as early diagnosis and treatment may help prevent complications and improve overall outcomes. By working together with your healthcare team and making lifestyle changes, you can better manage your symptoms and maintain your quality of life.

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